Cocaine caused pronounced increases in cerebral blood flow at 5 min postinjection that diminished markedly within 25 min. The results document the feasibility to conduct PET neuroimaging studies of cerebral blood flow in conscious nonhuman primates.
There are pronounced increases in the density (by a factor of 2) and in the ion pressure component P ixx (by a factor of the order of 5) ahead of the primary (dawnward) front and weaker increases in both quantities ahead of the trailing (duskward) front.
As Figure 3 shows the mean increase in FMD and peak diameter of week four is mainly due to two participants, who have very pronounced increases in their response.
In contrast to RSV and influenza A virus which showed pronounced increases in incidence in winter months, HRV-C infections occurred year round with similar incidence in each calendar month investigated in the current study (Fig. 2A), more comparable to adenovirus.
Following depletion of ER Ca2+ stores palmitate-treated podocytes showed more rapid and pronounced increases in ER Ca2+ refilling.
The pronounced increases in NLO response on moving along the series 2→ 4 are consistent with their steadily extending π-conjugated structures.
Using immunofluorescence, we found that both ACY-1215 and siRNA knockdown of HDAC6 induced pronounced increases in β-catenin at the plasma membrane.
The pronounced increases in the plasma concentration of urate that occur during chronic hyperuricemia can lead to supersaturation, and at concentrations >6.8 mg/dL, precipitation of monosodium urate (MSU) crystals can occur [ 6].
In agreement with this assumption, citicoline given orally to rats produced pronounced increases in plasma cytidine and choline, although it should be noted that the rise of cytidine was several-fold larger than that of choline [ 20].
However, as seen in Figure 2C, pronounced increases in Akt and ERK activation occurred following ligand-induced stimulation in the presence of dasatinib, whereas this was inhibited by LY294002 and U0126, respectively, as expected (data not shown).
Serious medical errors and pronounced increases in after-hours mortality have both been demonstrated in major teaching hospitals, whereas after-hours admissions to tertiary care intensive care units with on-site attending physicians are not associated with increased mortality.
