Sentence examples for pronounced defects from inspiring English sources
In the absence of zygotic γCOP activity, embryos die late in embryogenesis and display pronounced defects in morphogenesis of the embryonic epidermis and of tracheal tubes.
Indeed, mice deficient in TRPM8 [8]–[10] display pronounced defects in responses to pharmacological "cooling" agents and cold at both cellular and behavioral levels, illustrating that, in mammals, this channel plays a physiologically relevant role in the detection of environmental temperature.
In marked contrast, s6 mutants display pronounced defects in sporozoite gliding motility and salivary gland invasion.
We found that cells lacking Sgo2 had pronounced defects in attaching and segregating chromosomes correctly (supplementary Movie online).
The importance of μ-calpain activation in platelet function has been highlighted by the disruption of the mouse μ-calpain gene: μ-calpain−/− mice demonstrate pronounced defects in platelet aggregation and clot retraction.
For more than a decade, we have known that RPM-1 is broadly expressed in the C. elegans nervous system and that rpm-1 (lf) mutants have pronounced defects in neuronal development (Abrams et al. 2008; Schaefer et al. 2000; Zhen et al. 2000).
Ultrasmall CdSe nanocrystals are reported to exhibit pronounced defect emissions from surface trap states, which can be altered by the attachment of phosphonic acid ligands.
The pronounced defect of the Cik11 521 mutant points to an essential role for the non-catalytic head in the motility mechanism.
However, the expression of TT788/89AA or Y783/795F mutants in GD25 cells did not rescue the capability of C. jejuni to invade these cells; especially the FAK-signaling deficient GD25β1A-Y783/795F cexhibitedbited a highly pronounced defect for the uptake of bacteria.
We show that ztf-16 mutants exhibit pronounced remodeling defects, which are explained, at least in part, by defects in the expression of ver-1.
This patient who complained of different neurological symptoms and had changes in the CSF had a very good V/A, but pronounced field defects.
