The ability of MEKi to increase tumor immunogenicity supports clinical data currently emerging in solid tumors previously unresponsive to checkpoint blockade monotherapy36, 37. Interestingly, the effects of MEKi on MHC-I expression were most pronounced in the context of IFNγ.
Importantly, restoration of Dok-1 levels strongly suppresses transformation of cells expressing oncogenic tyrosine kinases, and this suppression is more pronounced in the context of a Dok-1 mutant that is largely refractory to oncogenic tyrosine kinase-induced degradation.
De Blasio's centrism becomes more pronounced given the context in which he's proposing his policies.
This is becoming most pronounced in the context of the workplace, which is having disastrous impacts on employee engagement and such prized qualities as innovation and creativity, which wither in a fear-based corporate habitat.
Such a tradeoff may be relatively pronounced in the context of starvation resistance.
At 4 years' follow-up, effects were principally maintained, albeit somewhat less pronounced in the context of some weight regain (31).
While biannual treatment yields only small additional health gains, its benefit is pronounced in the context of the elimination goals, shortening the time frames for and increasing the feasibility of reaching the proposed operational thresholds for stopping treatment.
The effect of the NLS mutation was more pronounced in the context of MRTF-A lacking its leucine zipper, suggesting that at least part of the residual activity is due to import with residual MRTF-A.
This is particularly pronounced in the context of fisheries: Overfishing is a globally acknowledged problem (FAO 2010), and accurate estimation of natural mortality is essential for sustainable fisheries management (Hilborn and Walters 1992).
Members of this latter class of mutants display stronger growth on galactose-containing medium (SC-his GAL) compared to glucose-containing medium (SC-his), suggesting that the chromatin defects leading to intragenic transcription initiation imparted by these H3-L61X mutares are more pronounced in the context of high levels of transcription.
As shown in Figure 3B, H4-R36A cells had modest growth on medium lacking histidine and containing glucose and much stronger growth on medium lacking histidine and containing galactose, indicating that cryptic initiation occurs in H4-R36A cells and that this defect is much more pronounced in the context of elevated levels of transcription.
