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Chilling of the Northern Hemisphere was pronounced: cold summers, incessant rains, floods, and resulting poor harvests, according to medieval records.
Mutagenesis studies of the C-terminal, catalytic domain of HSLadi has failed to identify the structural basis for the cold adaptation of HSL and provide an explanation for the more pronounced cold adaptation of rat HSLadi compared to human HSLadi [17], raising the possibility that the N-terminal domain impact the psychrotolerant properties of HSL.
The UCP1 knockout mice are able to maintain their body temperature, but suffer in pronounced cold exposure suggesting that UCP1 is principally involved in short-term adaptation to cold (Enerback et al. 1997).
PCA revealed a very pronounced cold acclimation-induced effect for levels of the ribosomal 40 and 60S subunit (see Additional file 4: Table S2) indicating a systematic reprogramming of the translational machinery in both accessions (Fig. 5).
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Jack Straw, the British Foreign Secretary, pronounced the Cold War "kaput" and called the new Reykjavik agreement its funeral.
After the brandy, I started drinking Scotch, and Miller drank bourbon, and, although the weather was warm enough that the central air-conditioner was running, he pronounced it a cold night and lit a fire in his fireplace.
The adjusted map had more pronounced hot and cold spots than the crude map.
The adjusted pancreatic cancer map showed more pronounced hot and cold spots compared to the crude analysis.
The reduction in free sugars was more pronounced in the colder harvest season (2010 2011).
It is possible that the loss of modification affects fine-tuning of ribosome function that could give rise to the pronounced cold-sensitivity.
The selected symptoms then were: breathlessness during activity, breathlessness even at rest, dizziness, cold sweat, pronounced tiredness, chest pain, pressure/discomfort in chest and worry/anxiety.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com