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It is suggested that each carotid artery segment could be influenced by different sets of genes [21] and be prone to variant pathophysiologic mechanisms [22].
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Conventional methods to analyze genome-wide association studies and whole exome or whole genome sequencing studies would be prone to overlook variants which might exert a recessive effect on risk of disease, either as homozygotes or compound heterozygotes.
We started from the assumption that cancer cells are prone to acquire mtDNA variants due to their continuous replication (Coller et al. 2001).
It has been reported that ID, as one of the splice site recognition mechanisms in eukaryotes, was prone to produce RI variants and the retained introns were usually shorter than the constitutive introns [ 35].
Comparison of transcriptome-level data obtained during the non-inducing and inducing steady states identified changes in expression of only about 1%% of the genome during production of either an amyloidogenic human lysozyme variant prone to intracellular aggregation (I56T) or a misfolded but secretable variant (T70N), indicating near-complete acclimation to their production.
Agriculture, particularly prone to systemic and co-variant risk, doesn't easily lend itself to insurance.
Like rice pathogen Magnaporthe grisea, C. lunata has a high degree of genetic variability and prone to form novel pathogenic variants to infect the resistant host.
Accordingly, these genes seem to be the least conserved regions of the human mtDNA and the most prone to harbor non-synonymous variants (Supplementary Fig. 4a), as previously reported in Mitomap.
The increase in MVD values from luminal to mural variant confirms that the mural variant is more belligerent and prone to recurrence, while the intraluminal and luminal variants are thus amenable to treatment by enucleation and curettage.
Functional disease-associated variant is prone to under the evolutionary constraint.
The I56T form is the least stable variant known and is prone to intracellular retention and minimal secretion, while the T70N variant is both more stable than I56T and more effectively secreted (Kumita et al. 2006: Whyteside et al. 2011a).
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