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Public data is sparse (on average a single compound is tested on two proteins) and prone to experimental error (on average 0.5 log units for IC50 data) [6, 7].
Unfortunately, in the past, ROS measurements have mainly been performed using isolated mitochondria, a method which is prone to experimental artifacts and does not reflect the complexity of the in vivo process.
Meanwhile, EBI3 knockout mice are less prone to experimental metastasis of B16F10 [43].
Although seemingly simple to establish, CHI models are particularly prone to experimental variability.
Condition (ii) alone is error prone to experimental data from dense graphs, which raises the probability to measure noise.
In general, however, heterologous expression systems, either transient or stable, have the major drawback of being prone to experimental artifacts.
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Matthew, as a visual learner, is more prone to use experimental configurations of text loosely inspired by E.E.
IL-17 deficient mice are less prone to develop experimental arthritis and blocking IL-17 can reduce both the onset and progression in these models [ 6].
This represents a significant advance compared to existing technologies, which involve either complex steps of pre-selection for nucleosome-containing chromatin or pre-amplification of precipitated DNA, making them prone to introduce experimental biases.
This may pinpoint modeling errors (in the model constraints or in the assumption of maximizing growth), but also errors in gas measurements: these measurements are generally less reliable, since they are based on determinations of the exhaust gases flow and concentration, which are prone to substantial experimental deviations.
However, the use of experimental methods to screen databases containing millions of small molecules [2] that could match with a target protein, for instance, is often very time-consuming, expensive and error-prone due to experimental errors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com