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Mice that expressed the SmoA1 transgene and that were either wild-type or deficient in expression of Pten were prone to development of tumor in the developing mouse cerebellum.
It was reported that genetically-engineered RASAL2 knockout mice are prone to development of several sporadic tumor, including lung adenocarcinoma.
These results strongly suggest that, compared to oseltamivir, IFV is less prone to development of resistance against DFSAs through NA mutations.
Large-scale comparative analysis of drug-target polymorphism structures enables the rational design of next generation 'super drugs' – drugs that are less prone to development of drug resistance or that work for the largest possible fraction of the patient population.
B. Regarding the choice of SD rats, EFSA notes that this "strain of rats chosen is known to be prone to development of tumours over their life This is neither taken into account nor discussed in the Séralini et al. (2012) publication".
Although advances in MI therapy have improved acute survival rates, such as percutaneous coronary intervention or coronary artery bypass graft, survivors are prone to development of chronic degenerative changes as a result of irreversible cardiomyocyte loss, extracellular matrix fibrosis, and pathological gene programming [3, 4].
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Composite rock failure criterion and geomechanical models between fracture density, aperture, strike and strain energy density were used to determine the quantitative development of fractures and predict zones that are prone to fracture development.
They suggested that this high expression of genes in normal PZ could support malignant growth, thus making the PZ more prone to tumor development [ 21].
Leishmaniasis threatens poor areas population worldwide, requiring new drugs less prone to resistance development.
Disease etiology and clinical course typically differ from that of adult-onset rheumatoid arthritis, and sufferers are prone to the development of other rheumatologic diseases, including rheumatoid arthritis.
Neurofibromatosis type 1 (NF1) is one of the most common brain tumor predisposition syndromes, in which affected children are prone to the development of low-grade gliomas.
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