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This epigenetic remodeling can indeed cause a susceptible state, in which cells are more prone to acquire genetic alterations, going through transformation and tumor progression.
Cells exposed to ionizing radiation, ultraviolet light or chemicals are prone to acquire multiple sites of bulky DNA lesions and double-strand breaks.
Alternately, these particular clones may be more prone to acquire foreign genetic material.
Secondly, tuberculosis HIV-1 co-infected patients in a hospital setting appear prone to acquire drug resistant bacteria such as ESBL and MRSA organisms.
Therefore, we concluded that, although CIMP-associated CpG islands may be prone to acquire DNA methylation in certain culture conditions, BRAFV600E does not specifically induce CIMP in COLO 320DM cells.
Indeed, our results show that these sublines are prone to acquire karyotype modifications.
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However, goats require a large range area and are indiscriminate in their food consumption making them prone to acquiring infections.
17 Improvement efforts are also prone to acquiring a 'project' status that can bring opportunities but also threats.
Cells from the tumor vasculature are generally non-transformed and less prone to acquiring drug resistance [ 3].
The negative sign of these genetic correlations indicates that animals that are genetically prone to acquiring IBK infection are also genetically prone to slower growth/weight gain.
In contrast, S. Enteritidis was less prone to acquiring resistances than other serotypes as described previously in Spain and other countries [ 6].
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