Sentence examples for prone stretch from inspiring English sources

Interestingly, we found that between300% and 39% of all proteins in these organisms contain at least one aggregation prone stretch (Table S4 A).

S. pombe, D. melanogaster and H. sapiens contain at least one aggregation prone stretch of at least seven consecutive residues that TANGO assigns a high score.

In addition, we observed that the former group harbors aggregation prone stretches more often than the latter.

Identification of Aggregation-Prone and Non-Aggregation-Prone Proteins in Each Structural Class We identified aggregation prone stretches in the proteins of the S group by using the TANGO algorithm (Fernandez-Escamilla et al., 2004 ) and aggregation prone stretches in the proteins of the U group by using the algorithm described by Michelitsch and Weissman (Michelitsch and Weissman, 2000 ).

Hence, highly hydrophobic, aggregation prone stretches facilitate aggregation of structured proteins, but thermodynamic stability and the fording/unfolding mechanisms will affect the real "aggregation potential" of these hydrophobic residues in a given protein.

Since continuous stretches of aggregation prone amino acids have been shown to be the driving force behind protein aggregation (Chiti and Dobson, 2006 ), we believe that the total number of aggregation prone residues in a protein is a less relevant criteria compared to the presence of aggregation prone stretches of amino-acids.

Since AGGRESCAN reports aggregation prone residues in all proteins of S. cerevisiae, we classified proteins as non-aggregation prone (XNA), if they had no aggregation prone stretches, defined as 4 or less consecutive residues that have av score greater than 0.5.

For the analysis presented in the main text, we did not consider proteins in the M group in order to (i) ensure that we are unambiguously dealing with highly unstructured and structured proteins and (ii) identify the effect of the presence of aggregation prone stretches on the cellular availability of proteins in each group.

For the analysis presented in the main text, we did not consider proteins in the moderately unstructured (M group) in order to (i) ensure that we are unambiguously dealing with highly unstructured and structured proteins and (ii) to identify the effect of the presence of aggregation prone stretches on the availability of proteins in each group.

But for six months last year, on a short but notoriously deer-prone stretch of Stephen Hands Path — a pretty road that cuts north from Montauk Highway — all was quiet.

coli), there is a bias towards the presence of residues with a low aggregation propensity flanking aggregation-prone stretches and that chaperones seem to have evolved to recognise these sequence features [27].