The developed algorithms are then used to estimate ASD on seven different crash prone segments in the Province of Alberta, Canada and the ASD is compared to the required SSD on each highway.
However, so far we know very little about the regulation of many proteins that are known to form β sheet aggregates in a cell or proteins that contain aggregation prone segments that are conserved for functional reasons.
Consequently, remedies/drugs designed to inhibit the aggregation tendency of this 'aggregation-prone' segment of NT-proANP may assist in prevention/treatment of IAA, congestive heart failure (CHF) or atrial fibrillation (AF).
The scenario is baffling to safety advocates and senators who think it is a bad idea to put the most crash-prone segment of the population behind the wheels of big rigs on the nation's interstates.
The mutated p53 is structurally destabilized, exposing the aggregation-prone segment, resulting in co-aggregation with wild-type p53 as well as paralogs p67 and p73.
For example, RDT1 might form a homo-oligomer or a complex with other proteins, in which the aggregation-prone segment is sequestered deep within a protein fold.
Repair of both homologous and nonhomologous repair-prone segments, characterized by high or low levels of recruited RAD51, respectively, was delayed.
We then tested whether simply generating tandem repeats of short, aggregation-prone segments within these domains would likewise be sufficient to create prion activity.
Under certain circumstances it is possible for the aggregation-prone segments to "recruit" a globular counterpart within the inclusion body, with the latter being able to fold into an active conformation.
Here, we identified and verified four "aggregation-prone" segments of apoA-I with amyloidogenic properties, utilizing electron microscopy, X-ray fiber diffraction, ATR FT-IR spectroscopy and polarized light microscopy.
