A notable feature is that they take into account the commonly observed ligand target binding interactions in an implicit manner, which obviates the need of explicitly modeling the error-prone interactions, including solvation and entropic effects.
It remains unclear whether chemotherapy backbones with irinotecan are less prone to interactions with mutated KRAS because data regarding this issue are conflicting.
The results of this study indicate that decrease in GNPs size produces an exponential increase in surface area relative to volume, which may make the GNPs more self-reactive (i.e., may promote aggregation) and more prone to interactions with surrounding molecules (biological components).
Unfortunately, the hERG-channel is particularly prone to interaction with a huge range of pharmaceutical compounds (Vandenberg et al., 2001).
Some promiscuity is tolerable if the sites prone to interaction are used in constructs in a mutually exclusive manner.
Absence of centromeric heterochromatin might cause increased kinetochore flexibility, making it more prone to interaction with microtubules coming from opposite poles.
As a result, Rovis next turned to Rh complexes, which are well-known to be less prone to interaction with Lewis bases such as halides.
These methods have good performance in general mesh segmentation but require time-consuming and error-prone user interaction when dealing with special and complicated tooth shapes and arrangements.
A third series of experiments shows that UNCD surfaces are not prone to unspecific interactions with highly-fouling proteins such as bovine serum albumin (BSA) but nevertheless some interaction will take place.
Patients in the intensive care unit (ICU) are more prone to drug drug interactions (DDIs).
Self-treatment of depression with herbal over-the-counter medicine St John's wort makes pain patients prone to drug interactions.
