Non-native and aggregation-prone forms of mutant SOD1s are thought to trigger the disease.
Besides their functions in Ca2+ homeostasis, PS1 and PS2 may have an additional role in AD, as they are part of the γ-secretase catalytic domain and presenilin mutations accelerate (although with different degrees of activity) the production of 'aggregation-prone' forms of A β1−42.
NHEJ is a potentially error-prone form of repair that is initiated with the binding of the KU70/KU80 heterodimer to DNA ends which then recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).
NHEJ represents the more error-prone form of DSB repair with faster repair kinetics than HRR.
In recent decades, a ketosis-prone form of diabetes that does not necessarily fit the typical characteristics of autoimmune type 1 diabetes mellitus has been identified.
This idea was tested using C. elegans as a model organism where formic acid (FA) has been used previously to solubilize an aggregation-prone form of GFP (Link et al., 2006).
ERPO may represent an ER quality control pathway for multiple ER substrates, since aggregation-prone mutant forms of seipin that are associated with an autosomal dominant motor neuron disease, accumulate in the same compartment [ 27].
"We" are prone to all forms of psychic distress, anxiety, depression, schizophrenia.
Still, his overall point is clear: The draft system has been full of loopholes, prone to many forms of favoritism and corruption, and unsatisfactory for civilians and military alike.
Infection by a Toxoplasma gondii could make some individuals more prone to some forms of neuroticism and could lead to differences among cultures if enough people are infected, says Kevin Lafferty, a US Geological Survey scientist at the University of California, Santa Barbara.
They are more prone to other forms of illness and disease, and find it harder to access health care.
