A key result of this work is the confirmation that the distributions and dimensions of architectural elements are controlled by salt-related faults and topography, with higher dimensional variability and lower continuity of sand-prone elements occurring in the vicinity of salt ridges.
I describe the use of a statistical mechanical model of a heirarchical network of failure-prone elements as a model for the failure of a network of interconnected biological elements that are or could be involved in the causation of cancer.
Increased beta-sheet aggregation potential of proteins is associated with the presence of aggregation-prone elements, such as hydrophobic and Q/N-rich stretches (Krobitsch and Lindquist, 2000; Michelitsch and Weissman, 2000).
In other words, the combined effect of DNA breakage-prone elements in addition to the arrangement of KIR genes in close head-to-tail orientation facilitates the rapid diversification of gene CNV in the cluster.
Additional sequence and structure features, such as the thermodynamic stability of a protein, its folding/unfolding pathway, and involvement in physical interactions with other proteins in a cell, will affect the manifestation of the aggregation-prone elements described above and, ultimately, the likelihood of the protein to aggregate in vivo.
Sand-prone architectural elements identified in this work include: a) axial canyons incising a salt-withdrawal basin (Unit 1), b) turbidite lobes intercalated with heterogeneous mass-transport deposits (Unit 2), and c) channel complexes confined by salt-controlled topography (Unit 3).
With limited financial and technical means, natural resource managers and policy makers can therefore help decrease soil loss at a large scale by promoting wise management of highly erosion-prone landscape elements and enhancing the use of low-erosion-inducing practices.
The finding that the Josephin domain of ataxin-3 contains highly aggregation-prone nonpolyQ elements opens new questions about the role of polyQ expansions in promoting ataxin-3 aggregation: Why does ataxin-3 cause SCA3 pathology only on polyQ expansion?
The preserved deposits of fluvial meander belts typically take the form of patchworks of sand-prone bar-form elements bordered by genetically related, muddy channel fills.
At present, it is unclear why some gene-rich regions, but not others are prone to L1 element insertion.
