AD is a stress-prone disorder that involves the autonomic nervous system.
The importance of SLX4 is demonstrated by the observation that biallelic mutations in SLX4 (also known as FANCP) are associated with the cancer-prone disorder Fanconi anemia (Bogliolo et al., 2013; Kim et al., 2011; Stoepker et al., 2011).
In a large number of patients with inherited cancer-prone disorders such as ataxia-telangiectasia, Nijmegen breakage syndrome and hereditary retinoblastoma an enhanced chromosomal radiosensitivity has been demonstrated (Sanford et al, 1989; reviewed in Scott et al, 1999).
Defects in these processes can result in a mutator phenotype associated with tumorigenesis, as exemplified by a number of familial cancer-prone disorders, including xeroderma pigmentosum (XP), Bloom syndrome (BS), ataxia telangiectasia (AT), Werner syndrome (WS) and Li-Fraumeni syndrome (LFS).
He presented a picture of human beings as essentially emotional and prone to disorder and evil unless controlled within a tight political structure dominated by rulers, priests, and the threat of the public executioner.
In a briefing to Mrs Thatcher written while he was a Downing Street aide in 1985, he claimed that white people were not prone to disorder and suggested that a scheme to encourage black entrepreneurs would only result in them investing "discos and drugs".
Screening for heterozygous mutations in the gene homozygously mutated in the cancer-prone, radiosensitivity disorder, ataxia-telangiectasia (ATM: AT mutated) in radiosensitive patients has been vigorously pursued during the past few years.
Local and regional data have shown that the same level of BMI connotes a greater degree of obesity in Asians compared with Caucasians (25), and that Asians are prone to disorders such as diabetes, hypertension, and dyslipidemia at lower levels of BMI than Caucasian populations (25).
Clues to the role of the DNA damage sensors, ATM (ataxia telangiectasia mutated) and ATR (ataxia telangiectasia related) kinases, their cell cycle targets and role in DSB repair were aided by the identification of three genes involved in cancer prone human disorders.
Healthwise, Scottish Terriers can be more prone to bleeding disorders, joint disorders, autoimmune diseases, allergies, and cancer than some other breeds of dog and there is a condition named after the breed called Scotty cramp.
However, ex vivo correction of cancer-prone genetic disorders necessitates a totally pure population of stably transduced stem keratinocytes for grafting.
