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Prompt ascertainment is crucial for the management of hyperammonemic infants.
Study designs that include prompt ascertainment and treatment of infections in the absence of symptoms may modify long-term protection.
As the indications for and benefits of antiviral treatment for congenital CMV disease in early infancy are refined, increasing awareness and prompt ascertainment of congenital CMV is important to ensure identification of all infants who might benefit from early treatment.
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We suggest amendments to reporting formats such as: number of participants who started per arm, total number of deaths from any cause per arm and the time point of last ascertainment to prompt study investigators to sum up all deaths across participant loss, primary or secondary outcomes and serious adverse events.
The required radiographic assessments, however, may have resulted in increased ascertainment of symptomatic events prompted by more intense clinical evaluation following an abnormal imaging study.
The stringent definition of exposure, the carefully and thorough information gathered and the objective ascertainment of the cases are the main strength of our study; also, by using prompt cards –a series of colour pictures including the drugs of interest, we could avoid or highly reduce recall bias.
We believe our ascertainment and pathological confirmation of meningioma for all cases and structured interview including visual prompts to ascertain hormone therapy exposure provide reliable data on disease and exposure history.
Even with clear instructions and prompts for trials to report deaths, however, there may be remaining uncertainty depending on the rigour of ascertainment or surveillance and the selection of trial outcomes.
% prompt.
Later, he added, "Open hearings are more conducive to the ascertainment of truth".
Prompt service.
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