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This event is indicative of an incomplete progression of the S phase and depletion of a fundamental protein promoting transition from G2 to M phase.
A role for Nanog in promoting transition to pluripotency has been also shown in vitro in reprogramming experiments (Silva et al., 2009).
Thus one possible explanation for the association of IκBα polymorphism with intestinal-type gastric cancer was that different production of NF-κB inhibitor IκBα mediated by IκBα polymorphism led to different NF-κB activation and downstream Cdx-2 expression, promoting transition from inflammation, intestinal metaplasia to carcinoma.
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In line with this hypothesis, structural signatures of the cancer mutational hotspot may manifest in deleterious protein stability changes in the inactive state of the enzyme, thereby promoting transitions to the constitutively active kinase form.
This suggests that health risks for this group may not be eliminated, but sizable benefits may still be realized by promoting transitions from unhealthy obesity into its healthier counterpart.
This article focuses on three components: adaptive competence as end state, constructive learning as lever for the transition to desired end states, and learning environments to promote transition.
The consequences of the alternative views of the 'timber famine' for contemporary policies attempting to promote transition to low carbon or sustainable energy use are examined.
We conclude that C/EBPβ directly transactivates p57 to promote transition from proliferation to hypertrophic differentiation of chondrocytes during endochondral ossification.
C/EBPβ transactivates p57Kip2 to promote transition from proliferation to hypertrophic differentiation of chondrocytes during endochondral ossification, suggesting that the C/EBPβ-p57Kip2 signal would be a therapeutic target of skeletal disorders like growth retardation and osteoarthritis.
It might be more difficult to promote transition of both the polyQ tail and the globular GST to the β-rich structure of the large aggregate for steric hindrance reasons.
We then considered whether constitutive expression of Nanog might be sufficient to promote transition to pluripotency in serum-free conditions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com