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Identification of mis-spliced genes promoting transformation will uncover novel targeted therapies.
Here we show that expression of H3.3K36M in HT1080 fibrosarcoma cancer cells severely impairs cellular proliferation, which contrasts its role in promoting transformation of chondrocytic cells.
Above all, it may heal by promoting transformation and positive awareness and that is something we all can use in life.
Thus, this result suggests GATA6 deficiency influences ovarian surface epithelia, possibly promoting transformation though tissue specific deletion of GATA6 in ovarian surface epithelial cells will be a better test, when GATA6 conditional knockout mice become available.
PAR1 has been recognized as an oncogene, promoting transformation in NIH 3T3 cells [ 65].
KSHV can also infect lymphocytes, promoting transformation into primary effusion lymphoma (PEL) or Multicentric Castleman's disease (MCD) in immunodeficient patients [ 2, 3].
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Viswanathan, S. R. et al. Lin28 promotes transformation and is associated with advanced human malignancies.
Results showed that HA pretreatment of wastewater not only promoted transformation from POM to DOM, but also boosted biodegradability.
The biology of migratory grasshoppers or locusts involves hormones that promote transformation of nonmigratory, solitary, shorthorned grasshoppers into gregarious hordes of locusts capable of causing great destruction.
Pomerleau V, Landry M, Bernier J, Vachon PH, Saucier C. Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.
MEK activation through the MAPK signaling cascade is necessary for mammalian cell transformation, and constitutively active MEK mutants promote transformation of fibroblast cells [14, 15].
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