mTOR inhibition promotes the processing of the miR-21 transcript (pri-miR-21) to a premature form (pre-miR-21).
This enzyme is conserved from yeasts to mammals, and, depending on the species, promotes the processing of stalled and/or broken replication forks, the repair of interstrand crosslinks, and the formation of crossover recombinants during meiosis [12], [13].
CAPS is due to gain-of-function mutations in NLRP3, a major protein of the inflammasome platform that activates pro-caspase-1 into its active form caspase 1, which in turn promotes the processing of the potent pro-inflammatory cytokine interleukin-1β [12].
Doxorubicin activates the NLRP3-inflammasome to promote the processing of pro-ILβ to mature IL-1β.
As illustrated above, there are additional sites for intervention to promote the processing of potentially functional sarcoglycan mutants.
Evidence indicates that pharmacological disruption of serotonin neurotransmission promotes the processing of mnemonic information by cerebral regions subjected to strong DA modulation.
Identification of this factor would reveal a possible crucial function of the sarcoglycan complex and provide a candidate drug to promote the processing of sarcoglycan complex.
Here, we show that oA β promotes the processing of pro-interleukin (IL -1 β IL -1mature IL-1 β intoicroglia, which then enhances maturelial neurotoxicity.
Furthermore, miR-125b can regulate a downstream target, lin-28 homolog B (LIN28B), in HCC cells, and subsequently indirectly promote the processing of let-7.
It has been shown that specific RNA-binding proteins, such as hnRNP A1, promote the processing of a specific mir-17-92 mir-17-92 mir-17-92Guil and component2007).
