Your English writing platform
Discover LudwigSuggestions(1)
Exact(3)
Indeed, the chief target of happiness policy advocates has been, not theories of justice, but governments' overwhelming emphasis on promoting GDP and other indices of economic growth.
When a ligand activates a GPCR, it acts as a GEF, promoting GDP to GTP exchange in the G alpha subunit.
DENND4A can also activate the RAB10 protein, which is a key regulator of polarized sorting in epithelial cells, from an inactive GDP-bound form to an active GTP-bound form through promoting GDP → GTP exchange.
Similar(56)
Rab1 activation by TRAPP therefore proceeds via a pathway in which the P-loop lysine does not interact with switch II, but is stabilised by an acidic residue from the GEF thereby promoting GDP-release.
Yet local officials have stuck with this model of development because it promotes GDP growth, and such measures are closely tied with their personal political careers.
Likewise, TTP promotes GDP reduction, and dGTP promotes ADP reduction (Brown and Reichard, 1969; Rofougaran et al., 2008; von Döbeln and Reichard, 1976).
To this end, we tested if ISRIB can promote GDP release from unphosphorylated eIF2 in the presence eIF2-P by mixing [H]-GDP-loaded eIF2 with eIF2-P in a 3 1 or 1 1 ratio.
Ligand binding to the G protein-coupled receptor promotes GDP release and its replacement by GTP, which results in a switch to an active conformation and dissociation from the other subunits (beta and gamma), allowing the GTP-bound alpha subunit to activate its effectors.
Rab5 activation by Rabex therefore proceeds via an alternative pathway in which the conserved switch II aspartate interacts with the P-loop lysine to promote GDP-release.
GDP/GTP cycling is regulated by guanine nucleotide exchange factors (GEFs) that promote the GDP dissociation and GTP binding, whereas GTPase-activating proteins (GAPs) have the opposite effect and stimulate the hydrolysis of Rho-GTP into Rho-GDP.
Furthermore, Bet3, a subunit of TRAPP1, functions as the GEF that promotes GDP-to-GTP switch in Rab1, thereby enabling vesicles to dock at the Golgi membrane through Rab1-GTP-Rab effector association.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com