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For a constant per base per genome mutation rate, reducing genome size also reduces the mutation load which is an important factor in promoting fixation of genomes reduced through deletion events [ 18].
It accelerates the formation of bone collagen in combination with calcium, in addition to effectively promoting fixation of dissociated intracellular calcium and preventing release of calcium from bone cells.
To the best of our knowledge, the evolutionary nature of the immuno-editing process has been studied until now under the framework of the so-called "modern synthesis", following which the environment (in our case the immune system) is not the "causative agency" [ 47] but a mere selective force promoting fixation of adaptive genomic changes [ 47].
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This rearrangement promotes fixation of male-benefit alleles regardless of their fitness effects when expressed in females (female expression is hypothetical, since the alleles are never transmitted to females).
Positive selection appears to promote fixation of indels in the N-terminal region of CatSper1 in mammalian species.
Perhaps there is an upper limit of AT% that is permitted in a genome and this upper limit may have promoted fixation of the genes encoding enzymes involved in RNA editing.
The distinction from the Darwinian route of evolution is straightforward: in the latter, the environment is not the causative agency but merely a selective force that may promote fixation of those random changes that are adaptive under the given conditions.
We proposed a scenario in which the Pleistocene climate oscillations led to the repeated restriction and expansion of the ranges of the ancestral species of the STR, which may have promoted fixation of ecological adaptations and morphological traits in small and isolated populations restricted to refugia.
Thus, "pre-adaptation" owing to phenotypic mutation would promote fixation of the second mutation which will be beneficial even without the first one – if the selective advantage of the complex trait is high enough (the ultimate situation that helps understanding is that this trait is essential for survival).
In addition, park designs have been shaped by a number of theories: Attention Restoration Theory (ART), for example, predicts that natural scenes promote fixations, and these allow the brain to recover from extended periods of concentration.
Galtier et al. [ 45] noticed that GC-biased gene conversion, frequently accompanied by an increase in GC3, influenced the evolutionary trajectory of human proteins by promoting the fixation of deleterious AT→GC mutations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com