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In agreement with previous reports [8] [10], we found that knocking out pRb production in osteoblasts had profound consequences on cell adhesion, altering the expression profile of osteoblast cadherins and other cell adhesion molecules, promoting disruption of adherens junctions, and producing abnormalities in bone structure.
In the following months, communists began promoting disruption of the execution of the Marshall Plan by means of open confrontation with local governments.
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This condition then promotes disruption of intracellular calcium regulation, resulting in calcium deposition [23, 34, 35].
This EGFR activation was shown to promote disruption of adherens junctions through induction of MMP-9.
Integration of viral DNA into host genome is essential for carcinogenesis since it promotes disruption of the HPV E2 gene, leading to abnormal expression of E6 and E7 oncoproteins.
Specifically, cleavage of CD44 could promote disruption of cell-ECM contacts and promote cell cell contacts that drive sphere formation.
This insertion promotes disruption of existing lipid microdomains and alters the formation of these structures after promastigote internalization [ 42, 43], causing the exclusion of Syt V [ 44].
Supporting our hypothesis, a decrease in phosphatidylethanolamine species promotes disruption in calcium homeostasis resulting in hepatic ER stress and insulin resistance in obesity (Fu, et al., 2011).
When HPV integration occurs, it promotes disruption of the HPV E2 gene, leading to abnormal expression of E6 and E7 oncoproteins (Arias-Pulido et al, 2006).
The involvement of lysosome in the intracellular trafficking routes of both iRGD-cMLVs and cMLVs might facilitate drug release kinetics because enzymes, such as phospholipases, in the endolysosomal compartments can promote disruption of liposomal bilayers [ 46, 47].
These sites have been shown to help with crystalline starch hydrolysis and also help promote disruption of α-glucan interchain binding at the surface of granular starch, thereby enhancing enzymatic degradation of crystalline starches by glucoamylase I [ 30, 31].
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