Sentence examples for promoting disaggregation from inspiring English sources
The Hsp104 disaggregase, in contrast to the conserved and canonical Hsp70/40 chaperones, cannot prevent protein aggregation and is only affecting protein aggregation by promoting disaggregation [ 19].
Curcumin can bind senile plaques and promote disaggregation of existing amyloid deposits and prevent aggregation of new amyloid deposits.
In yeast, Hsp104 was found to promote "disaggregation" of stress-induced protein aggregates, along with the aid of the Hsp70 family of chaperones and the Hsp26 and Hsp42 families of small heat-shock proteins.
Second, reduced signaling through the insulin signaling pathway appears to suppress proteotoxicity by two distinct mechanisms: heat shock factor one (HSF-1) promotes disaggregation of toxic intermediates while the FOXO transcription factor DAF-16 promotes the formation of large molecular weight aggregates, which are apparently no longer toxic [ 9].
Although the role of amyloid deposits in the pathogenesis of the disease is not clear, preventing their formation or promoting their disaggregation is necessary to control the development of clinical symptoms.
Less is known about the role of cyclophilins in Leishmania, though these peptidyl-prolyl cis/trans isomerases have been shown to reactivate cellular proteins by promoting their disaggregation [ 71].
By binding tightly to hydrophobic surfaces, HSP70 limits such interactions and promotes disaggregation".
Curcumin inhibits Aβ fibril formation and promotes disaggregation of existing fibrils in vitro with IC50 values of 0.19 to 1 μM [ 9, 11, 12], although much higher IC50 values in the 10 to 12 μM range have been reported [ 13, 14].
A-type EGCG dimer could not only dramatically promote the disaggregation of the preformed bovine insulin amyloid fibrils, but also restructure the amyloid fibrils into amorphous aggregates.
This exchange alters G alpha subunit conformation and promotes the disaggregation of the heterotrimeric complex.
Furthermore, HSP104, HSP70, and HSP40 destabilize prions and promote their disaggregation [ 98].
