Staff reductions mean she is highly unlikely to be promoted; budget constraints ensure that many of the perks she came to expect have been removed.
Counteracting the pathway proactivation mechanism, binding of NSP to the kinase domain promotes steric constraints that impair intermolecular phosphorylation at Thr-474 within the NIK A-loop.
Instead, our findings are in line with an earlier suggestion [8] that the visual performance of poikilothermal insects follows environmental and behavioral constraints, promoting signal integration in cold and dark conditions and enhancing response speed when it is warm and bright.
It is conceivable that RNase 8 is under constraints promoting selection of a novel function, perhaps only partially-related to its original role; as such, rigid adherence to the structure that is required for enzymatic cleavage of polymeric RNA is no longer necessary or useful.
Thus, the core 4E10 epitope was extended and modified to a WFX(I/L)(T/S XX L/I)W motif, where X does not play a major role in 4E10 binding and can be used to introduce helical-promoting constraints in the peptide epitope.
On the other hand, major constraints in promoting the use of this service include personal constraints, privacy and freedom of travelers, and limitations of carpooling service such as time-consumingness and unpunctuality.
Poverty was delineated as a main constraint for promoting health after childbirth.
Following this idea, the network identification problem is formulated as an optimization problem with the objective of promoting sparsity given the constraint of maximizing predictive capacity.
A molecular docking study of the closed ligase using AutoDock 4.2 defines additional specificity constraints promoted by the Ω-loop capping the catalytic center.
Emergency situations or crises are often characterized by limited access to adequate safe food and water, as well as disruptions in health and nutrition services and constraints to protecting, promoting and supporting optimal infant and young child feeding.
Contextual environmental factors may influence health by placing constraints on (or promoting) health-related behaviors (e.g., smoking, alcohol use, poor diet, physical inactivity), or through acting as a source of (or buffer against) stressors [ 5].
