Sentence examples for promoting breakdown from inspiring English sources

MMP-19 can degrade various ECM proteins in vitro and, thus, could be predicted to act in an anti-fibrotic manner by promoting breakdown of the ECM.

In particular, we focused on the impact of TNF α on sensitivity to SMCs as we hypothesized that SMCs could convert this pro-inflammatory cytokine that is present in the mesothelioma microenvironment into a potent apoptosis inducing cytokine by downregulating cIAP1 and 2 and, thereby promoting breakdown of the pro-survival TNFR1 Complex I and formation of the pro-apoptotic Complex II.

Based on these results, we conclude that brain endothelial P2RX7 is likely to be a key and early requirement for inflammatory activation in SE and that its effect occurs at least in part via activation of the inflammasome and NLRP3/caspase-1/IL-1β signaling to promote breakdown of the BBB and neurovascular injury during SE.

Oxidizing, dry conditions favor the stabilization of secondary phases, while promoting oxidative breakdown of the primary sulfides.

The roles of the pre-existing channel defects exposing the substrate surface and of the spurious interfacial oxide promoting coating breakdown and/or delamination are emphasized.

The process is also important in promoting the breakdown of leaf proteins into free amino acids and increases the availability of freed caffeine, both of which change the taste of the tea.

In the succeeding steps of the exchange reaction, the approach of GTP-Mg <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0009142.e164.PNG" class= inline-graphic"/> would then act to reverse these effects, promoting the breakdown of the close interactions between Arf1 and the GEF in the nucleotide-free intermediate II.

Our results indicate that TG2, mostly through its TGase activity, plays a critical role in experimental arthritis by promoting the breakdown of cartilage components by synovial cells.

Moreover, they showed that sugar can also suppress MIR156 expression by promoting the breakdown of MIR156A and MIR156C primary messenger RNA transcripts.

IL17 increases the turnover of type I collagen through both inhibiting its synthesis and promoting its breakdown [ 35], and members of the IL17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation [ 36].

By promoting the breakdown of the endothelial basement membrane, MMP-2 allows the migration of endothelial cells and the formation of primitive vessels into avascular regions of tissue [ 7].