To do so would promote tension between neighbors and, even worse, might leave some folks too fearful of retribution to make legitimate complaints.
After carefully selecting attractive young people in their 20's and early 30's, the producers look for ways to promote tension and conflict.
In addition, input from the Dachsous-Fat pathway to Hippo signalling is mediated via the atypical myosin Dachs, which has been shown to promote tension at apical cell cell junctions (Mao et al, 2011).
A serious concern, he said, is that if the American shield develops without a dialogue, then hard-liners on each side who describe "worst case" threats will be strengthened, promoting tensions and a race between offensive and defensive weapons.
Thus, Eps8 promotes cortex tension and increases intracellular pressure.
10.7554/eLife.08314.014 Figure 4. Actin bundling by Eps8 promotes cortex tension and intracellular pressure to drive leader bleb formation.
We find that Eps8 bundling activity promotes cortex tension and pressure to drive MAT in non-adherent, confined cells, which migrate with a characteristic 'leader-bleb' morphology.
Cells confined in a non-adhesive environment migrate in the direction of a very large 'leader bleb.' Eps8 bundling activity promotes cortex tension and intracellular pressure to drive leader bleb formation.
Thank you for submitting your work entitled "Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration" for peer review at eLife.
These results show that the actin bundling activity of Eps8 facilitates the formation of large leader blebs by promoting cortical tension and intracellular pressure.
