Exact(3)
Excess aldosterone promotes potassium excretion.
Luminal tissue kallikrein promotes potassium secretion by stimulating ENaC activity and sodium reabsorption in the principal cells, as described above [ 16, 20].
In the collecting duct, the ENaC resides on the apical membrane of principal cells and mediates sodium reabsorption without chloride, increasing the lumen electronegativity and creating an electrical gradient that promotes potassium and hydrogen ions secretion into the urine.
Similar(57)
In this study, the equilibrium and non-equilibrium models for CO2 absorption from natural gas stream by DEA-promoted potassium carbonate solution in a tray column were developed and compared with each other.
However, drugs such as acetazolamide promote potassium excretion by impeding hydrogen-linked sodium reabsorption [ 11].
In contrast, 5-HT2C activation facilitates cell depolarization by inhibition of specific potassium channels promoting potassium outflow (Weber et al. 2008).
W341C is able to induce potassium loss in Bacillus subtilis and Streptococcus lactiae and promote potassium uptake into Escherichia coli [ 95].
Treatment includes stabilizing the cardiac membrane with intravenous (IV) calcium, shifting potassium into cells with IV insulin and albuterol and promoting potassium excretion with sodium polystyrene sulfonate or hemodialysis.
Furthermore, because one of the effects of aldosterone is to increase potassium excretion, suppression of the renin-angiotensin-aldosterone system by ACE inhibitors, angiotensin II receptor antagonists, or aldosterone antagonists tends to promote potassium retention.
First, antagonize the effects of hyperkalemia at the cellular level (membrane stabilization) by administering calcium gluconate; secondly, decrease serum potassium by promoting potassium into cells through co-administration of glucose and insulin and thirdly, remove potassium from the body by dialysis or treatment with potassium-binding resins.
Impaired renal function may also promote potassium retention, as the ability of the kidney to excrete excess potassium is reduced, and mild-to-moderate renal insufficiency is common in patients with advanced heart failure, especially in patients with concomitant conditions such as diabetes (Sica et al. 2003).
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