Since CBF3 binds to and promotes expression of the RD29A promoter, RD29A-CBF3 functions as a cold-induced self-amplicon, which will feedforward the expression of the RD29A promoter.
Another sequence element, the "Gamma Promoter Element" (GPE1), which also promotes expression in neuron-like cells, lies 70 bp downstream of the second major TSS.
HGF-dependent Met activation in transformed epithelial cells promotes expression of a malignant mammary epithelial phenotype [8].
Another example of TNF-induced Notch activation is observed in a mouse pancreatic cancer model where TNF promotes expression of Notch target genes Hes1 and Hey1 (Maniati et al., 2011).
The term 'M2' has also been used to describe M-CSF generated macrophages [34] with evidence that M-CSF stimulation promotes expression of a considerable portion of the M2 transcriptome [27].
For example, Snail, a known inhibitor of E-cadherin expression, also promotes expression of the αvβ3 integrin, which is associated with a pro-invasive phenotype and activation of TGF-β [46,47].
Furthermore, anisomycin induced activation of p38MAPK can phosphorylate SRF, which further promotes expression of immediate early genes [45].
In C. elegans, the DAF-16 transcription factor in the insulin signaling pathway promotes expression of stress resistance and longevity genes.
These results indicate that crude bile specifically promotes expression of Vp-PAI genes and that this induction is regulated by vtrA.
TNF also promotes expression of an array of "protective" genes including the zinc finger protein A20, heme-oxygenase-1 (HO-1) and Bcl-xL [12].
Gcn4 is a master transactivator that promotes expression of ∼400 genes, including those encoding enzymes involved in amino acid biosynthesis [23].
