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Mechanistically, we showed that PHGDH inhibition promotes differentiation by differentially regulating the stability of Oct4 and β3-tubulin proteins.
Fig. 5: PHGDH KD promotes differentiation of ECSLCs through differential-ubiquitination of β3-tubulin.
(g) Loss of indicated signalling in basal cells promotes differentiation.
Fig. 6: EZH2 represses TBX3 in RD cells and promotes differentiation of ARMS and ERMS cells.
Our results showed that depletion of EZH2 promotes differentiation in both ARMS and ERMS cells.
Taken together, the data clearly showed that modest depletion of EZH2 inhibits proliferation and promotes differentiation.
Moreover, under basal (physiological) conditions, the product promotes differentiation of OPCs.
We suggest that Lgl1 promotes differentiation by supporting NG2 routing to the lysosome.
Together, these results suggested that PHGDH inhibition promotes differentiation in ECSLCs.
Fig. 4: TBX3 inhibits proliferation and promotes differentiation in RD cells.
Yi, R., Poy, M.N., Stoffel, M. & Fuchs, E. A skin microRNA promotes differentiation by repressing 'stemness'stemness
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