Sentence examples for promoter role from inspiring English sources

Studies in PKCδ −/− mice have confirmed a pro-apoptotic role for this kinase in response to DNA damage and a tumor promoter role in some oncogenic contexts.

These properties are assigned to the high dispersion of nickel and to the promoter role of the support: actually, after the catalytic test, intermetallic nickel cerium compounds (CeNi and CeNi2) are detected in the sample in addition to the Ni0 phase.

In addition, the slight improvement of BW through supplementation of 1 % mushroom wastes could be explained by the oligosaccharide existence in the mushrooms cell wall and its growth promoter role as a prebiotic which may have positively affected the microflora balance of the intestinal tract (Chou et al. 2013).

Notably, termination factors play an additional promoter role by restricting non-productive RNA synthesis in a Pol II CTD S2P-specific manner.

We observed that loss of E-cadherin leads to impaired primary and metastatic tumor formation in vivo, suggesting a tumor promoter role for E-cadherin in addition to its known role as a tumor suppressor.

The promoter role of oestrogens in breast cancer has been evidenced by epidemiological studies indicating an increased incidence in women with prolonged exposure to oestrogens and a drastic decrease in incidence in women having nonfunctional ovaries (Pike et al, 1983).

These observations suggest that bivalent promoter roles should be further investigated in these cells.

However, consistent with a context-dependent role in cell death regulation, both tumor suppressor and tumor promoter roles have been described for BNIP3.

Our present incomplete understanding of the precise mechanisms for the dual tumour suppressor/tumour promoter roles of the TGF-β superfamily ligands represents a major obstacle to targeting these molecules for the treatment of human cancer [ 20].

The present study showed that the level of expression of TβRIII decreased in TSCC and this may facilitate our better understanding of the dual tumour suppressor/tumour promoter roles of the TGF-β in early- and late-stage human cancers.

When overactivated, macroautophagy induces senescent cell death, hence reinforcing the tumor-suppressive role of senescence already assigned to its cell cycle arrest effect; when only moderately activated, macroautophagy favors senescent cell death escape and the new generation of neoplastic cells, hence contributing, in contrast, to a tumor-promoter role of senescence.