Sentence examples for promoter achieved from inspiring English sources

Thus, as this promoter achieved long-term dystrophin expression in the mdx mouse [6], it might be a candidate promoter for gene therapy of murine muscular dystrophy models.

Kubo et al. showed that replication-competent Ad driven by the midkine promoter achieved antitumor responses against mesothelioma [ 51].

Here we omitted the hAAT promoter element to achieve higher specificity, as the original hybrid APO E-hAAT promoter achieved too high activity in HEK 293 cells in pre-experiments (data not shown).

Although the CAG promoter achieved extensive transgene expression in the mouse CNS, transduction of antigen-presenting cells with vectors containing ubiquitous promoters may trigger strong cell-mediated immune responses.

Previously nonobese diabetic (NOD) HIIE α-HSP60 Tg mice, in which HSP60 is driven by the MHC class II-E α (HIIE α) promoter, achieved HSP60 expression specifically in the thymus and bone marrow and suppressed susceptibility to autoimmunity induced DM [ 31].

The observation that the MTTR Pol II promoter achieves good expression of anti-HBV sequences is a useful property for the development of gene therapy requiring liver-specific expression of antiviral RNAi mimics.

The polyhedrin promoter achieves the highest yields in the ICE system [ 37- 40], but because it is also compatible with the WGE and RLL systems [ 38] we assumed it would also be functional in the BYL.

Indeed, we have recently reported that intracerebroventricular (ICV) delivery of AAV6 combined with a cmv promoter allows targeting up to 80% of spinal motoneurons in newborn mice, while ICV injection of AAV9 combined to the gfaABC1D promoter achieves transgene expression in at least 50% of ventral horn astrocytes.

Furthermore the SM22-promoter achieved much better expression rates and expression levels in the TE-671 cell line than in the HEK 293 cells when compared to the EF1α-promoter.

Taken together, the SM22-promoter achieved better expression rates and expression levels in the TE-671 cell line, confirming its usefulness as a tissue-specific promoter for muscle-specific cells.

Furthermore, the usage of neuron-specific promoters achieved selective transduction of neurons.