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In cultured human hair follicles, TRPV1 activation suppressed hair shaft elongation, promoted apoptosis, inhibited proliferation, and promoted transition to catagen, all reminiscent of the effects of cannabinoids.
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This article focuses on three components: adaptive competence as end state, constructive learning as lever for the transition to desired end states, and learning environments to promote transition.
The consequences of the alternative views of the 'timber famine' for contemporary policies attempting to promote transition to low carbon or sustainable energy use are examined.
We conclude that C/EBPβ directly transactivates p57 to promote transition from proliferation to hypertrophic differentiation of chondrocytes during endochondral ossification.
C/EBPβ transactivates p57Kip2 to promote transition from proliferation to hypertrophic differentiation of chondrocytes during endochondral ossification, suggesting that the C/EBPβ-p57Kip2 signal would be a therapeutic target of skeletal disorders like growth retardation and osteoarthritis.
It might be more difficult to promote transition of both the polyQ tail and the globular GST to the β-rich structure of the large aggregate for steric hindrance reasons.
We then considered whether constitutive expression of Nanog might be sufficient to promote transition to pluripotency in serum-free conditions.
These results demonstrate that constitutive expression of Nanog promotes transition to pluripotency in serum-free medium with LIF.
By activating CCND2 and other CDKs and suppressing cell cycle inhibitors, MYC promotes transition into S phase.
A role for Nanog in promoting transition to pluripotency has been also shown in vitro in reprogramming experiments (Silva et al., 2009).
In conclusion, we provide evidence that PKC η promotes transition of keratinocyte proliferation to differentiation via the upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling.
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