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Although not well understood, induction of intracellular UA accumulation in pancreatic cancer cells (PANC-1) following radiation exposure or treatment with 5-fluorocracil was found to mediate the induction of MHC class-I related proteins MICA/B that in turn promoted sensitivity to NK-92 cell killing[152].
They identified several kinases, including CDK5, which promoted sensitivity to a PARP inhibitor when silenced in CAL51 cells.
This potential mechanism does not explain our 14-3-3 14-3-3 14-3-3he other isoform that promoted sensitivity to stressors, as 14-3-3 σ was not findings bind parkin or althe its functiother
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The result is an integrated activation that promotes sensitivity transitions and the signals are then perceived.
In our opinion, the result is an integrated activation that promotes sensitivity transitions and the signals are then perceived.
We conclude that the mechanisms of rapamycin resistance in hepatic cells involve alterations of signaling downstream from mTOR and that the mechanisms are highly heterogeneous, thus predicting that maintaining or promoting sensitivity will be highly challenging.
It is therefore likely that therapeutic approaches that aim to normalize the tumor microenvironment and/or interrupt the crosstalk between the tumor cells and the microenvironment, will not only help to stall the progression of cancer, but also have a potential to promote sensitivity of tumors to chemotherapy or radiotherapy.
Oncogenic transformation promotes sensitivity to inhibition of certain metabolic pathways (synthetic lethality).
The solvent system and sample preparation were carefully selected to reduce the matrix effect on ionization and promote sensitivity.
For ovarian cancer cells, silencing of Bmi-1 gene could promote sensitivity to cisplatin and induction of apoptosis [ 39].
Most cancer treatments induce autophagy in the remaining, resistant cancer cells, with inhibition of autophagy promoting sensitivity to therapy.
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