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9 Other initiatives that promote trials on medicines in children include US and EU legislation.
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For example, combining breast services between smaller hospitals and academic hospitals might promote trial entry.
All stakeholders should promote trial registration and posting of results, and support initiatives that facilitate searches across multiple trial registries (strong recommendation).
The government has promoted trials of retired military officers; unlike previous trials in the 1980s, which ended in an amnesty after threats of military coups, these ones have not included any guerrilla leaders.
It clearly makes sense for the trial population to reflect as far as possible the wider group in which the therapies will ultimately be used, and Stead et al (2011) in this issue of the journal report on 10 years experience of the National Cancer Research Network in promoting trials in the UK.
Instead, she said, doctors too often promoted trial treatments as superior to standard approaches, even when there was no supporting evidence.
Members of the International Committee of Medical Journal Editors (ICMJE) promoted trial registration in 2004 by publishing a statement on it.
The 2004 ICMJE statement promoting trial registration had defined 1 July 2005 as a key date for prospective trial registration (registration before recruitment started).
This means to design, finance, and promote clinical trials that focus on demonstrating the advantages of using the hybrid technologies to properly address unmet clinical needs.
The germline mechanisms disrupted in serrated polyposis patients and the somatic mutations found in sporadic MSI-H tumors should promote clinical trials of newly developed chemotherapeutics for sporadic serrated colorectal tumors.
In particular, from 1997 the US FDA with the 'Modernization Act' and from 2002 the European Medicines Agency (EMA) with the consultation paper 'Better Medicines for Children' undertook actions to promote clinical trials in children for both authorized and investigational medicinal products [ 6, 7].
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