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Activation of Hippo signaling and increased phosphorylation of Yap/TAZ has been shown to promote their interaction with β-catenin, increasing cytosolic retention of β-catenin, and thereby negatively regulating Wnt/β-catenin signaling [59].
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Once in the nucleus, PERs might physically bridge CRYs and CLOCK-BMAL1 and promote their interactions (Chen et al., 2009).
The location suggests that upon low pH exposure in the endosome, the protonation of these histidines may promote their interactions with the neighbouring negative charged lipid head groups and anchor E2 to the lipid membrane, thus facilitating the separation of E1-E2 heterodimers along with the E1 homotrimerization.
Convergent evolution of extracellular parasite proteins to promote their interactions with host tissues is well documented [ 40, 41], and we identified O. viverrini ORFs encoding membrane and secreted proteins, some of which were clearly more similar to vertebrate than to invertebrate homologues (Table 3).
Having established the successful recruitment of both the enzyme and the inhibitor protein on the BTA polymers, we next explored whether the recruitment on the supramolecular platform promotes their interaction.
Then, we verified the interaction between p65 and SUMO2/3, and found TNF-α promoted their interaction.
Auxin changes the conformation of receptors and thereby promotes their interaction with Aux/IAA proteins.
In addition, the local concentration of the binding interfaces near their target site is increased, which promotes their interaction (40).
It does so by binding to SMAD4 and to the non-specific co-activator p300 and promoting their interaction [ 10].
Such phosphorylation activates the E3 ligase activities of Cbls and promotes their interaction with numerous proteins 1, 2, 23, 25.
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