Bioinformatics studies have also recently suggested that an additional contribution to protection mechanisms against aggregation may be encoded within protein sequences themselves, through specific residue patterns that promote stabilizing interactions and protect solvent-exposed aggregation-prone regions (14).
Similar to the above-mentioned distance change between S3.39 and D2.50, the positional shift of T2.39 away from D/E3.49 may promote and stabilize protonation of the latter.
Genetic studies indicate that FtsW is required for productive FtsZ ring formation and that FtsW possibly functions to promote and stabilize Z-rings in mycobacteria [34].
First, actin may be involved in the formation of the M lattice that may promote and stabilize its curving, resulting in the enhancement of some late processes, such as virion budding and release.
Ligands of CCR5, in contrast to a ligand of CXCR4, induced a clear increase in FRET efficiency, indicating that selective ligands promote and stabilize a distinct conformation of the heterodimers.
A total of 15 proteins that promote or stabilize protein folding in the ER were detected.
The need for this lipid modification to promote and stabilize membrane association of certain CPKs has been experimentally demonstrated [ 37].
Thus the upregulation of Cx43 may promote and stabilize the formation of junctional complexes and further maintain keratinocytes in a non-proliferative state.
They could also redirect agonist action to alternative downstream signalling pathways, as they promote or stabilize transient conformations of the unliganded receptor, which then possibly pre-dispose to its selection by an agonist for the promotion of a particular set of downstream events, while the receptor would be selected for another set of downstream events when no autoantibody is bound.
Although the mechanism remains unclear, the authors propose that the presence of Gprc5a may promote the stabilizing interaction between β-arrestin and IκBα.
Notably, pressure-induced polymerization, mainly 1D polymerization, is promoted and stabilized by light irradiation.
