The major biologically active derivative of vitamin A, all trans retinoic acid (RA), is known to promote specification of a number of endodermal phenotypes during development including lung [24], kidney [25], intestine [26], and pancreas [27], however its role in urothelium formation is currently unknown.
The Runx1/CBFβ holocomplex therefore serves as a coincidence detector for extrinsic and intrinsic signals that promote specification of nonpeptidergic nociceptors.
The assays may lead to artefactual inductions that change initial commitment of a cell and promote specification in an alternative direction.
ID4, in particular, inhibits OPC differentiation through direct binding to Olig1 and Olig2, class B HLH transcription factors that promote specification and differentiation of oligodendrocytes (Lu et al., 2002; Mekki-Dauriac et al., 2002; Rowitch et al., 2002; Takebayashi et al., 2002; Zhou and Anderson, 2002; Rowitch, 2004; Ligon et al., 2006).
The openEHR foundation aims to facilitate interoperable implementations of electronic health record systems (EHRs), by developing and promoting open specifications and specifications-based implementations.
Summary: In differentiating hESCs, BRACHYURY has cell type-specific targets and functions: it acts with SMAD1 to promote mesoderm specification, while in the endoderm it interacts with SMAD2/3.
These principles promote the specification of the structure and the runtime behavior of the domain-specific languages as the central part of the development process.
Matrix metalloproteinases (MMPs) remodel the extracellular matrix (ECM) to facilitate epithelial-to-mesenchymal transitions (EMTs) and promote cell specification during embryonic development.
Our data demonstrated that BMP4 was sufficient to promote PGC specification in the CDM.
Both ARF3 and ARF4 promote the specification of the abaxial leaf fate [19].
