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These subjects had participated in a 1-year randomised, placebo-controlled, double-blind study to evaluate the potential of a tumour necrosis factor α blocking monoclonal antibody to slow down destruction and to promote remodelling of the affected finger joints.
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iMSCs were then encapsulated in poly ethylene glycol diacrylate (PEGDA) hydrogels grafted with adhesion peptide (RGDS) to promote remodeling and further maturation into VIC-like cells.
Together, these data suggest that EDCn-HGF microthreads recapitulate several of the regenerative cues lost in VML injuries, promote remodeling of functional muscle tissue, and enhance the functional regeneration of skeletal muscle.
These contacts sandwich the Hin dimers to promote remodeling into the tetramer.
The function of MMP-2 is to degrade ECM proteins and promote remodeling and regeneration of bone tissue [ 10].
We found PTRN-1 to be distributed in puncta along neurites, and these structures thus represent a potential reservoir for sensors that promote remodeling.
Furthermore, they promote remodeling of the extracellular matrix by inducing an imbalance in the system of metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases (TIMPs)) [ 37, 51, 54].
Of note, replacing IGF-1 with EGF promoted remodelling of human colonic crypt morphology followed by multiple budding events characteristic of intestinal organoid growth (see online supplementary figure S6).
Western blotting showed that levels of heterochromatin markers HP1α and H3K9me3 were up-regulated upon VC treatment, indicating that VC promotes remodeling of heterochromatin to a younger state.
Depletion of myofibroblasts promoted remodeling of the pancreatic tumor stroma as well as changes in immune cell infiltration to the tumor.
In conclusion, mild diabetes can stimulate a gene expression pattern that promotes remodeling of both micro and macrovessels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com