These results shed light on a novel mechanism through which PCa cells educate OCys to promote progression of PCa bone metastasis.
SPARC-induced changes in the tumor microenvironment can suppress or promote progression of different cancers depending on the tissue and cell type.
Zhou SL, Zhou ZJ, Hu ZQ, Huang XW, Wang Z, Chen EB, Fan J, Cao Y, Dai Z, Zhou J (2016) Tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to Sorafenib.
There is trepidation with the use of anticoagulation for isolated MCAD-related ischemic syndromes as it may promote progression of intramural hematoma within the dissection [5], whereas others hypothesize that anticoagulation may slow the progression of thrombosis that could otherwise lead to a fusiform aneurysm [17].
Thus, factors which promote progression at any of these stages should be enriched in individuals suffering severe disease and death.
Polarization of macrophages is a characteristic of both cancer and infection, and may promote progression or resolution of disease.
RB is a repressor of E2F transcription factors, which function to promote progression from G1 to the S phase of the cell cycle [7].
The c-Myc gene product can act both directly and indirectly on CDK4 and thereby promote progression into S phase and DNA synthesis [32], [33].
An interesting aspect of this finding is the ability of CLN1 and CLN2 to form a complex with CDC28 to promote progression through the cell cycle [12].
Recently, Aoyama et al. [21] reported that challenge with P. gingivalis, but not with A. actinomycetemcomitans (an aggressive periodontal pathogen), could promote progression of aortic diameter in an experimental model AAA.
Alternatively, air pollution may actively promote progression to otitis media.
