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Since the factors that promote errors are not directly visible in the working environment, they are described as latent risk factors (LRFs).
Processes that increase the rate of changes in DNA are called mutagenic: mutagenic chemicals promote errors in DNA replication, often by interfering with the structure of base-pairing, while UV radiation induces mutations by causing damage to the DNA structure.
Our experience (Long et al., 2009) is that segmentation errors promote errors in the subsequent recognition task in a non-additive fashion.
9 At the most fundamental level, EHR software itself can be poorly designed and may promote errors such as radiation overdosing or miscalculating patient medication doses.
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Other approaches that promote error resiliency combine concealment and forward techniques.
Pol κ and pol ζ together promote error-free replication through oxidative DNA damage, cis-thymine glycol.
It has been proposed that the de novo cohesion establishment tethers the DNA dsb damaged strand with its identical and intact sister chromatid counterpart to promote error-free DNA repair [ 7].
Second, to promote error-prone recombination or TLS extension reactions that are required for ICL processing (Sharma & Canman, 2012), FANCJ might remove MSH2 that is bound to DNA mismatches.
In conclusion, our results suggest that replication-associated chromatin architectural changes act as a novel layer of regulation, besides the molecular switch mediated by PCNA ubiquitylation/SUMOylation, to control DDT pathway choice and to promote error-free replication under conditions of genotoxic stress.
The latter was confirmed by Salanitro et al. 31 Two studies by Field et al 32 33 reported morbidity as promoting errors.
It has been proposed that Bcl6 inhibition of p53 transcription is required for promoting error-prone DNA repair in germinal center (GC) B cells undergoing clonal expansion, CSR and SHM without inducing an apoptotic response19.
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