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This would presumably promote detachment and release from a mature biofilm based on degradation of the relevant S. aureus adhesins and/or extracellular matrix components including extracellular DNA.
It is possible that, in the preparation phase of regeneration, TGF-β1 could be expressed to promote detachment and migration of mesenchymal cells towards the blastema.
Shedding of ICAM-1 is thought to promote detachment of leukocytes from the endothelium, thus limiting local inflammation [ 10].
However, the nature of events that promote detachment and apoptosis of podocytes and whether detachment occurred simultaneously with apoptosis are still unclear.
If tethered in the inner centromere, Aurora B is active, but does not efficiently promote detachment of microtubules from the kinetochore.
The cells formed a single thin layer after 2 weeks of plating, at which time the UpCell dishes were placed at 25°C for 30 min to promote detachment of the cell sheet from the bottom surface of the dish [ 11].
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Technology is often seen as disconnecting people from one another promoting detachment, isolation, and fostering a faux intimacy by creating virtual 'relationships.' But technology is also a cohesive force especially in the legal industry.
A major role of the S. cerevisiae Aurora kinase Ipl1p is to drive chromosome biorientation on the mitotic spindle by promoting detachment of kinetochores from microtubules when both sister chromatids are attached to microtubules from the same spindle pole [ 32, 33].
Overexpression of PDCD6IP restores contact inhibition, promotes detachment-induced apoptosis, and reduces tumorigenicity in nude mice [ 26, 27].
It is known that caspase activation is involved in cell detachment, to some extent mediated by caspase-3-mediated ROCK1 activation to promote cell detachment through increasing MLC2 phosphorylation.
Src can also promote the detachment of tumor cells from the primary tumor by downregulating E-cadherin and upregulating MMPs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com