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The coatings prevent the growth of bacteria that promote decay in the grooves of molars.
On the other hand, microRNAs (miRNAs), ∼22 nucleotide (nt) long RNA molecules, can repress gene expression by base-pairing with sequences in 3'-untranslated regions (3'-UTRs) of messages and thus inhibit their translation or promote decay [8], [9].
To date, the order of these events and the extent to which they promote decay remain controversial.
Dysregulation of these pathways can result from an imbalance in the expression of the RNA-binding proteins HuR and tristetraprolin (TTP) that stabilize or promote decay, respectively, of ARE-harboring mRNA transcripts.
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In concert with other factors, PUFs repress gene expression by inhibiting translation or promoting decay [16], [17], [18].
Although the exact molecular details are unclear, CBC interaction with UPF1 promotes NMD machinery assembly on the aberrant mRNA, promoting decay [ 150, 153].
Concerning the potential mechanisms of cccDNA decay, recent studies suggest that inflammatory cytokines, such as IFN- α and lymphotoxin- β, induce intrinsic cellular response to promote the decay of cccDNA through APOBEC3 family enzyme-catalyzed cytidine deamination and subsequent DNA repair process 51, 52.
Both sugars can promote tooth decay.
Our population needs to be better educated about the foods that promote dental decay.
In fact, health officials routinely discourage such habits, saying they promote tooth decay by transferring cavity-causing bacteria from a parent's mouth to the child's.
The potential of miRs to act in a combinatorial manner and to also promote mRNA decay creates conceptual and technical challenges in their study.
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