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Intriguingly, phosphorylation of Munc18c has recently been shown to decrease its interaction with Sx4 and promote an interaction with Doc2β [34].
The degree of functionality gives the total number of accessible regions in the sequence that may promote an interaction with another RNA molecule.
Although we, of course, cannot rule out that the interaction between Rif1 and PP1 proteins in either species is indirect, these results suggest that the PP1 docking motifs in Rif1 are functional and promote an interaction with the PP1 phosphatases.
Furthermore, ER calcium depletion did not promote an interaction between ERdj5-mCherry and CRT-GFP, as the FRET signal in cells co-expressing the proteins was unaltered by treatment with thapsigargin.
Overall, the results suggest either that the export of Upf3p occurs by binding to Upf2p or a specific export pathway for Upf3p is necessary to promote an interaction with Upf2p.
It is known that this heterogeneity of glass slide can result in adsorption of small polar molecules, such as water, and this can promote an interaction of PAM by hydrolysis at these sites [ 28].
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ER stress induces GRP78 expression and promotes an interaction between GRP78 and AKT, as shown by an in situ proximity ligation assay (PLA) and co-immunoprecipitation, which in turn suppresses Ser473 phosphorylation and thereby modulates substrate specificity.
It has been reported that during mitosis, Kap121 blocks Ulp1's access to its NPC-binding site and thus promotes an interaction of Ulp1 with septins [ 27].
In summary, our results indicate that disruption of actin filaments promoted an interaction between mitochondrial Ca2+ and cytoplasmic Ca2+, as generalized in our model.
In most of the studied GPCRs, binding of the sensed ligand molecule (agonist) causes a conformational change in the helical bundle that promotes an interaction with a GTP/GDP binding protein, which then triggers the intracellular signal cascade [ 4, 5].
In this study, we defined a novel role for BCAR3 in which it antagonizes the canonical TGFβ signaling by promoting an interaction between p130Cas and the Smad transcription factors.
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