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The C-terminal residues 1520 to 2301 promote affinity to chromatin but are dispensable for nuclear import.
Help from autoantigen (histone, Ku autoantigen, among others), activated T cells in germinal centers will further promote affinity maturation and isotype switching in autoreactive B cells.
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Restricted B cell signaling in the areas responsible for immune memory cell production promotes affinity maturation.
These innovations provided the evolutionary release from constraints that allowed the implementation of an AIS: whereas adipocytes buffer against the sudden metabolic demand associated with the activation of an AIS, vascular innovations decreased the cost of mobilising an antibody-based immune response and augmented the performance of an AIS (e.g., promoting affinity maturation).
The results show that an increase in concentration of β-CD in the prepared samples that leads to an increase in hydrophobicity seems to promote an affinity for albumin adsorption.
Due to the positive charge transferred from intercalating Li+ ions to adjacent C atoms, OH− could add on the graphene sheets and further promote their affinity to water, resulting in efficient exfoliation of graphene in water.
Parkinson, the son of a Yorkshire coal miner, clearly feels he has transcended his working-class roots, i.e. the very background he employed to promote his affinity with the British proletariat.
Phosphorylation of these residues provides the necessary chemical energy to promote high affinity interaction between receptors and β-arrestins (Gurevich and Gurevich, 2006).
Another example comes from the well-studied T3SS effector Tarp for which the enhanced phosphorylation found in LGV strains was shown to additionally promote high affinity interactions with proteins associated with the immune signaling pathways (Mehlitz et al. 2010), likely explaining the capacity of these strains to cross the mucosa epithelium and to infect mononuclear phagocytes.
By contrast, the conformations adopted by K48-linked chains may not promote high-affinity interactions with NleL, and as a result, processive chain formation does not occur.
Overall, these results suggest that targeting moDC can imprint the specialised programme of effector Tfh function needed to promote high-affinity B-cell immunity in vivo that, ultimately, boosts protein vaccine efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com