A deglycosylated form of VDBP, VDBP-macrophage activating factor, is able to promote activation of macrophages and osteoclasts, and even native VDBP may have effect on osteoclasts [ 21].
Murine caspase-11 and its human orthologs caspases 4 and 5 are activated by cytosolic lipopolysaccharides (LPS), and indirectly promote activation of caspase-1 through the non-canonical inflammasome pathway.
However, TLR signaling cascade, which can be activated in plasmacytoid dendritic cells, fails to promote activation in macrophages in response to HIV-1 [55].
Importantly, the results also pointed out three minimal promoter regions, A3, B3 and C, which were sufficient to promote activation by Nter-142Q (Fig. 3).
Meunier, E. et al. Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Wang, X. et al. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1 RIP3 DRP1 signaling pathway.
When the concentration was higher than 1.38 mM, they could promote activation of endogenous coagulation system and shorten the clotting time.
Seventy-three per cent of PIK3CA mutations localized to Glu542Lys, Glu545Lys and His1047Arg/Leu hotspots that promote activation, with the remaining mutations of uncertain function.
Tick bites promote activation of an inflammatory process that is influenced by bovine genetic composition and its history of previous exposure.
We examined whether loss of PARD6B or PARD6G might promote activation of key proliferation-related signaling pathways and explored the status of protein kinase B1/Akt among several other pathways.
The most promising therapeutic approach is to purge the latent HIV reservoir residing in CD4+ T cells with latency reversing agents (LRAs)—proteins or small molecules that promote activation of the latent virus3.
