A set of immune molecules that bind pathogen-derived antigens and display them on the surface of antigen-presenting cells to promote acquired immune responses.
These induced SOS genes include Y-family DNA polymerases, which catalyze error-prone translesional replication over damaged DNA and can promote acquired drug resistance.
Here, however, increased expression of HRG can not only promote acquired therapeutic resistance to HER TKIs, but it also can mediate primary resistance to lapatinib (see Additional file 8) [ 44- 46].
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Indeed, this crucial survival pathway promotes acquired resistance in a wide range of cancers, such as breast cancer, leukemia, ovarian cancer and non-small-cell lung carcinoma.
MiR-455 promotes acquired temozolomide resistance in GBM [ 58].
The biosynthesis of SA may culminate in the expression of resistance genes that promote systemic acquired resistance (SAR).
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In subjects who were already seropositive for a DENV type, we assessed whether there was an increase in antibody titer and whether primed subjects with less than tetravalent antibody responses were promoted to acquire tetravalent neutralizing antibodies.
Previously seropositive subjects were assessed by measuring an increase in each DENV antibody type and whether primed subjects with less than tetravalent antibody responses were promoted to acquire tetravalent neutralizing antibodies.
