Sentence examples for promiscuous pathway from inspiring English sources

Another hypothesis, referred to as the promiscuous pathway, suggests that AR can be activated by non-androgen antagonists.

One possible mechanism for abiraterone resistance can be gain-of-function AR mutations which sensitizes AR to non-androgenic steroids through the promiscuous pathway.

The mechanisms involved in an altered AR-signalling of CRPC cells include an over-expression/amplification of the AR (hypersensitive pathway), point mutations broadening ligand-specificity of the receptor (promiscuous pathway) as well as activation of the AR by peptide growth factors or cytokines (outlaw pathway) [ 17].

From these experiments, important molecular mechanisms were identified to contribute to the cancer development, including androgen amplification, promiscuous binding, outlaw pathway, bypass pathway, and androgen receptor coregulators [ 3, 4].

Along both pathways, promiscuous intermediate genotypes gained recognition of the novel SREs, followed by further replacements that eliminated high-affinity binding to the ancestral RE and any transiently acquired targets.

The mTOR/Akt/PI3K pathway is promiscuous and interacts with a number of other intracellular signaling networks, such as the IGF-1R or RAS pathways, which can allow treatment escape.

However, due to ROCK's promiscuous involvement in several pathways little certainty is gained regarding the regulatory signals that lead to an epithelial-to-mesenchymal switch.

Although protein interactions identified by the peptide-binding assay require formal validation using endogenous proteins, the observation led to the proposal by Selbach and Backert that the bacterial EPIYA motifs act as pathogenic 'master keys' that perturb multiple signalling pathways through promiscuous binding with SH2 domain-containing proteins (Backert et al., 2010).

To overcome these limitations, we developed an "IPP-bypass" isopentenol pathway using the promiscuous activity of a mevalonate diphosphate decarboxylase (PMD) and demonstrated improved performance under aeration-limited conditions.

These findings provide a rationale for the regulation of promiscuous antibiotic mechanisms by a pathway that can respond to self-derived signals.

The ten genes with greatest impact on higher alcohol formation were further characterized, including some not previously linked with this pathway: two highly promiscuous carboxylases (PAD1 and SPE1) and two dehydrogenases (OYE2 and HOM2).