Sentence examples for promiscuous active from inspiring English sources

We also explored the prospect of promiscuous active sites to serve as the starting point for directed evolution (DECAAF).

Their promiscuous active sites, however, also lead to fidelities that are much lower than those observed for other DNA polymerases and give rise to interesting mechanistic properties.

By rapidly and reversibly sampling sites, AlkA is able to maintain a remarkably promiscuous active site pocket that accommodates damaged bases of very different sizes.

Promiscuous activities are often inefficient because new substrates with different steric and electronic properties do not bind optimally relative to catalytic groups in the active site, and/or because additional chemical steps not required for the original activity are needed.

Engaging in promiscuous activity.

In this work, we assess the ability of a promiscuous, constitutively-active bEBP the AAA+ ATPase domain of DctD from Sinorhizobium meliloti to activate transcription from all σ-dependent promoters for the characterization of the σ regulon of Salmonella Typhimurium LT2.

In summary, the comparison of the YbdB and YdiI substrate specificity profiles reveals that both thioesterases are (i) promiscuous, (ii) most active with benzoyl- and phenylacyl-based thioester substrates, and (iii) significantly more active with a CoA-based thioester substrate than with the corresponding FAS holoACP-based substrate.

This is correlated with and reinforces stereotypes of males as active, promiscuous, and competitive, and females as passive, coy, and nurturing.

Catalase appears to be quite promiscuous, with two active sites that can participate in a variety of redox and condensation reactions.

The majority of currently available promiscuous compounds is active in the sub-µM range against two to five targets from the same family and displays potency differences against these targets within one or two orders of magnitude.

We validate our approach by introducing a promiscuous esterase activity in E. coli thioredoxin on the basis of mutations at positions close to the native-active-site disulfide-bridge.