Typical proteins are highly promiscuous [199,257,258] and there is increasing evidence for the comparative promiscuity of metabolites [259 261] and pharmaceutical drugs [26,39,199,262 271].
We have had 13-year-old rape victims described by police as "promiscuous", 14-year-olds called "slags" and countless others who won't speak to the police at all because they are too scared and ashamed.
Brave, contentious and blisteringly fast-paced, O'Neill refuses to give her reader any easy moral certainties in this examination of rape culture in a small Irish town - was promiscuous 16-year-old Emma O'Donovan's behaviour just "asking for it"?
It is now widely acknowledged that the single target paradigm (i.e. one protein/target, one disease, one drug) that has been the dominant premise in drug development in recent past is untenable as both drug-like compound (ligand) and target protein can be promiscuous [1, 2].
The lead character is a promiscuous 30-something (named Amy) who sleeps with who she wants to, when and where she wants - even making it all the way to Staten Island.
There was no sign that getting the shots made the teens more promiscuous: 53.9% said they were sexually active in the pre-vaccine years, and 50.3% were having sex after the vaccine became available.
CXCR1 is specific for IL-8 and GCP-2 while CXCR2 is more promiscuous [19].
Both sexes can mate with multiple partners, and females are extremely promiscuous [14], [15].
All of these compounds were evaluated biochemically in the presence of detergent (Triton X-100), to exclude the formation of detergent-sensitive promiscuous aggregates[14].
To determine whether MULAN is a bona fide E3, a GST fusion with its RNF was tested for the ability to mediate ubiquitylation in reactions utilizing the promiscuous E2, Ubc4.
In the current study, we have evaluated the polyfunctionality, longevity and memory phenotype of the HIV- specific T cell responses induced by HIVBr18, a DNA vaccine encoding promiscuous CD4 epitopes, in BALB/c mice.
