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Moreover, this prominent tolerance opens up more opportunities for a recombinant host to be applied in an appropriate fermentation process, using either growing cells or high-density resting cells, with different types of expression and process controls, e.g. batch, fed-batch, continuous or multi-stage continuous (Garcia et al. 2011).
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New Alliance is led by Naser Khader, a Syrian-born Danish citizen who became a prominent spokesman for greater tolerance in the Muslim world after widespread violence in response to a series of caricatures of the Prophet Muhammad in Jyllands-Posten, a leading Danish newspaper.
The phenotypes of heterozygous CBP-deficient mice show increased insulin sensitivity and glucose tolerance despite prominent lipodystrophy of white adipose tissue (Yamauchi et al., 2002).
The natural evolution process towards desirable properties like adaptability to low pH and inhibitor tolerance is prominent among industrial yeast strains where cells are repeatedly washed with dilute H2SO4 and recycled in the fermentation process along with pre-cultures as observed with the PE-2 strain used in Brazilian ethanol production plants (Della-Bianca et al. 2014).
HLA-G is a biologically interesting candidate gene because of its prominent function in immune tolerance.
Apart from overt changes, such as declining muscle strength, extensive metabolic alterations also occur with aging, one of the most prominent being impaired glucose tolerance [2].
Given the fact that KCC2 is a neuron-specific molecule, it is worth noting that low genic tolerance is prominent in relation to neurodevelopmental disorders 21.
The engineering of novel metabolic capacities into robust microorganisms may be easier than the alternative strategy, i.e. engineering of very high ethanol tolerance and prominent general robustness.
Some of these principles, such as the stronger constraints on the sequence evolution of essential genes, were previously hypothesized or evidenced using smaller data sets, but the most quantitatively prominent distinction on the tolerance of gene copy-number variations has been largely underappreciated.
The CBF/DREB-regulated network of genes has been shown to play a prominent role in freeze-tolerance of Arabidopsis through the process of cold acclimation (CA).
Genes like Haa1p-dependent TPO2 and TPO3 (Nrg1p-regulated [ 49]) show a prominent effect on acetic acid tolerance [ 57].
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