Sentence examples for prominent substrate of from inspiring English sources
Nevertheless, spectrin is a prominent substrate of the Ca2+-activated protease calpain and activation of calpain may result in the creation of fragments not unlike those we have expressed.
P130Cas (Crk-associated substrate) is a prominent substrate of the Src tyrosine kinase in the integrin adhesome that has been implicated in the control of cell migration [6], [7], [8], [9].
A prominent substrate of PKR is the alpha-subunit of the translation factor eIF2. Phosphorylation of eIF2alpha leads to an inhibition of translation.
Moreover, Tbdn was previously found in a complex with Cortactin, a filamentous-actin binding protein and prominent substrate of c-Src (Weed and Parsons, 2001; Paradis et al., 2008).
Cytokeratin 18 (CK18) is the major intermediate filament protein in the liver and one of the most prominent substrates of caspases during apoptosis of hepatocytes [10].
MARCKS is a prominent substrate for conventional and atypical isoforms of protein kinase C (PKC) (Hartwig et al., 1992; Herget et al., 1995).
Overexpression of cortactin, one of the most prominent substrates for Src, might therefore sequester Src from Cbl to prevent Cbl phosphorylation and thereby prevent its ability to ubiquitylate the EGFR.
CK-18, one of the most prominent substrates for lethal caspase activation, can be cleaved by caspases, primarily not only by caspase-9, but also by caspase-3 and caspase-7, and the subsequent release of CK-18 fragments into the extracellular space occurs during cell death [ 66].
Haeme synthesis shows controlled and complex regulation with prominent substrate inhibition at the first step of 5-aminolevulinic acid (5-ALA) production (Ponka, 1999).
The most prominent substrate aside from APP is the NOTCH receptor.
Increasing Rer1p expression levels thus results in lower γ-secretase levels and therefore less proteolytic fragments like Aβ or Notch intracellular domain, in the case of Notch processing, to name only two prominent substrates.
